Automatic Collagen Production Line

Automatic Collagen Production Line efficiently extracts and processes collagen from raw materials. It ensures consistent, high-purity collagen output through continuous operation with minimal manual intervention, enhancing yield and product quality for industrial-scale manufacturing.

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Design of Automatic Collagen Production Line

Raw material selection and pretreatment: chicken breast cartilage and fish scales are two commonly used collagen raw materials. These feedstocks were selected based on their high protein content and relatively easy accessibility. In the pre-treatment stage, de-ashing and enzymolysis are key steps to improve the extraction rate and quality of collagen. For example, citric acid de-ashing and ultrasonic-assisted de-ashing can effectively reduce the ash content of fish scales, while trypsin digestion can significantly increase the hydrolysis of bone collagen.

Extraction process: multi-stage counter-current solid-liquid extraction technology and coupled enzymatic reaction-membrane separation process are two effective collagen extraction methods]. These techniques enable efficient collagen extraction while maintaining a narrow molecular weight distribution and a low random degradation rate. In addition, the application of automated equipment, such as automated sol-gel systems, can further improve the efficiency and controllability of the extraction process.

Purification and quality control: isoelectric point precipitation and ultrafiltration purification techniques are two commonly used collagen purification methods. These methods can effectively remove impurities and ensure the high purity of collagen and the integrity of the triple helix structure. Meanwhile, Fourier Transform Infrared Spectroscopy, Circular Dichroism and other technical means can be used to analyse and assess the quality of collagen in detail.

Automation and optimisation of the production process: automated control systems play an important role in the collagen production process. For example, automated fermentation controllers can significantly improve the yield and quality of recombinant human collagen. In addition, the application of automated bioreactors, such as the Kerator, not only reduces labour costs, but also improves product stability and reproducibility.