Are you encountering the following problems in your current production?
1. Long drying time for wet cake and batch inconsistency / variability
2. Thermal degradation of sensitive materials
3. High dust generation / Poor containment
If mild mixing, efficient heat transfer, and solvent recovery are combined in a single device, the liquid-to-powder conversion can become a continuous, controllable, and scalable process, avoiding the aforementioned problems. This is the conical vacuum ribbon/screw mixer we are introducing.
Typical Application Scenarios
| Industry | Typical Materials/Process | Why is the conical vacuum screw belt suitable? |
| Pharmaceuticals / Active Pharmaceutical Ingredients | After synthesis or fermentation, the wet cake is dried; the sterile API is finally dried; and the intermediate is subjected to solvent replacement. |
Low-temperature resistant to degradation, closed solvent recovery system, and GMP-compliant cleaning validation-friendly design |
| Highly Active / Cytotoxic Drugs | Cytotoxic and hormonal APIs |
Fully enclosed system + dust-free discharge + compatible with isolators |
| Fine Chemicals / Specialty Chemicals | Dyes, pigments, catalyst precursors, and easily oxidizable intermediates | Inert gas protection + solvent recovery + antioxidant treatment |
| Food / Nutritional |
Probiotics, plant extracts, protein powder, vitamin premixes |
Maintains activity at low temperatures, ensures uniform final mixing, and prevents cross-contamination |
| New Energy Materials |
Lithium battery cathode/p precursor slurry → powder and viscous slurry drying |
The screw ribbon can break down adhesive properties, prevent powder agglomeration, achieve high filling rates, ensure complete discharge, and minimize loss of valuable materials. |
Production Advantage of Conical Vacuum Screw (Ribbon) Mixer-Dryer?
🔹1. Low-Temperature Vacuum Drying
Low Temperature: Protects heat-sensitive/easily oxidized materials;Vacuum lowers the solvent boiling point (water boils at approximately 35℃ under -0.095 MPa), allowing low-temperature drying (30–80℃)
Vacuum: Isolates oxygen, preventing APIs or active ingredients from oxidizing or discoloring, suitable for heat-sensitive and easily decomposable products
🔹 2. High Heat Transfer Efficiency - Shortens Drying Cycle
The screw continuously stirs the material, constantly renewing the heated surface, eliminating agglomerates; the jacket can optionally heat the hollow screw inside, providing an effective heat exchange area 1.2–1.4 times that of the vessel wall
Under the same volume, drying efficiency is typically 3–5 times that of double-cone rotary vacuum dryers
🔹 3. Multi-Function Machine, Reduces Costs
The same equipment can perform: vacuum drying, mixing, cooling, solvent recovery, reaction
Replaces multiple pieces of equipment such as "centrifuge → tray drying → pulverization → mixing," reducing material transfer, dust exposure, and cleaning validation workload
🔹 4. Fully Enclosed GMP Design
Top-driven, no bottom bearing, no dead corners inside the cylinder;
Nearly 100% bottom self-discharge, minimal residue, suitable for high-value or high-activity materials; optional CIP/SIP, aseptic design, ATEX explosion-proof configuration
🔹 5. Flexible Filling Rate and Low-Shear Mixing
The filling rate can operate normally within 30%–100% of effective volume while maintaining uniform mixing; low-shear screw movement protects crystal morphology
Customizable Equipment Parameters
Tank volume
Design Pressure
Tank/Jacket Material
Processing Temperature
Tank Size
Discharge Height
Sealing system
Motor
Dust Removal System
Agitator Type
Reducer
Condenser
Bearing
Feeding/Vacuum/Discharge Port
Pressure Transmitter
Frequency transformer
The above equipment parameters can be customized according to actual production needs and processed materials.
Equipment Compliance Requirements
- Material and Surface Treatment: 316L, Ra ≤ 0.4 μm
- Sealing System: Mechanical Seal / Magnetic Seal
- Optional Certifications: ASME, CE, ATEX, cGMP design, FDA related compliance design
- Document Support: DQ/IQ/OQ templates, FAT protocol
