freeze drying of pharmaceutical products

1. Drying and preservation of biological products.
In the field of biomedicine, there are many substances such as vaccines, serums, plasma, etc. that are preserved for a strict period of time, beyond which they will be inactivated and denatured, and thus have no medical value. As these products contain a large number of heat-sensitive biologically active substances, traditional high-temperature drying methods can easily lead to the destruction and inactivation of the active ingredients. But after freeze-drying by vacuum freeze-dryer, they can be preserved for a longer period of time without destroying the activity and stability.

2. Modernised production of traditional Chinese medicine.
In order to have a longer shelf life, most of the traditional Chinese medicines need to be dried. But the traditional way of treatment is mostly sun-drying and drying, drying efficiency is low, high temperature will also lead to the loss of the active ingredients in the drug. The emergence of vacuum freeze dryer is a good solution to this problem. Maximum to maintain the colour, smell and appearance of Chinese herbal medicines and other traits, while avoiding the oxidative decomposition of heat-sensitive components, to maintain the activity of the drug. For example, Yunnan Baiyao's whole panax ginseng tablets are improved by vacuum freeze dryer to increase the ginsenoside content, thus improving the medicinal properties.

Vacuum freeze-drying machine
3. Stability improvement of western medicine.
Vacuum freeze dryer can not only improve the content of active ingredients in traditional Chinese medicine, but also improve the stability of western medicine. Especially for intravenous drugs, it greatly reduces the degradation of drugs in storage and transport. Those drugs that are not stable in water can be made into lyophilised powder by vacuum freeze dryer. For example, the new crown vaccine is through this method to complete the cold chain transport.

The application of vacuum freeze dryer in pharmaceutical research and development not only improves the quality and stability of drugs, but also promotes the modernisation and innovation of the pharmaceutical industry. It provides new solutions to some previous medical problems. Sihuan, as a service provider specializing in providing customers with professional vacuum freeze drying equipment and solutions, can be personalized for customers to develop vacuum freeze drying equipment and supporting programs.

• Extends the shelf life of the medicine: by reducing the moisture content of the medicine, the growth rate of microorganisms and the occurrence of chemical reactions are significantly reduced.
• Preservation of active ingredients: the molecular structure of the drug is not significantly altered by the removal of water during the lyophilization process, so the drug is able to maintain the same efficacy as the original solution after re-dissolution.
• Improve dissolution speed and bioavailability: the microstructure of the drug is protected after freeze-drying, which makes the drug dissolve faster in the body and have higher bioavailability.

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We design and manufacture extraction prodcution line for users in need of a simple device for small amounts of extract, as well as more complex equipment for industrial use. Our offer includes preprocess(dryer /grinder) ,coating machine ,package machine and process systems where the substance used as solvent is either a volatile hydrocarbon (butane extraction), an alcohol (alcohol extraction), or CO2 (supercritical extraction). Given the investment cost, complexity of use, and extract quality, each system has some advantages and disadvantages.

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